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Pseudoephedrine is excreted through urine, and the concentration in urine of this drug shows a large inter-individual spread; that is, the same dose can give a vast difference in urine concentration for different individuals. [123] Pseudoephedrine is approved to be taken up to 240 mg per day.
The cinnamoyl-CoA is then reacted with a hydratase to attach the alcohol functional group. The product is then reacted with a retro-aldolase, forming benzaldehyde. Benzaldehyde reacts with pyruvic acid to attach a 2-carbon unit. This product then undergoes transamination and methylation to form ephedrine and its stereoisomer, pseudoephedrine. [89]
A decongestant, or nasal decongestant, is a type of pharmaceutical drug that is used to relieve nasal congestion in the upper respiratory tract. The active ingredient in most decongestants is either pseudoephedrine or phenylephrine (the latter of which has disputed effectiveness ).
That doesn't mean you shouldn't also use pseudoephedrine in addition to nasal steroid sprays or nasal antihistamine sprays, but it’s best to limit pseudoephedrine use to a short-term period. Dr.
Pseudoephedrine is the most common oral decongestant alternative, but since it has potential for abuse, you’ll likely need to ask a pharmacist for help accessing it behind the counter.
The U.S. Food and Drug Administration (FDA) announced that it plans to ban products containing phenylephrine, an ingredient found in many over-the-counter (OTC) oral cold and flu medications.
Until 2006, NyQuil Cold/Flu Multisymptom Relief and NyQuil Sinus contained pseudoephedrine (30 mg/15 mL), a nasal decongestant that also formed the active ingredient in Sudafed. Following the passage of the Combat Methamphetamine Epidemic Act in 2006, in the United States all pseudoephedrine-containing medications must be kept behind a pharmacy ...
Advisers to the Food and Drug Administration voted unanimously on Tuesday against the effectiveness of the key drug found in popular versions of Sudafed, Dayquil and other medications stocked on ...