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They worked primarily by suppressing appetite, and had other beneficial effects such as increased alertness. Use of amphetamines increased over the subsequent decades, including Obetrol and culminating in the "rainbow diet pill" regime. [38] This was a combination of multiple pills, all thought to help with weight loss, taken throughout the day.
Intentional weight loss is the loss of total body mass as a result of efforts to improve fitness and health, or to change appearance through slimming. Weight loss is the main treatment for obesity, [1] [2] [3] and there is substantial evidence this can prevent progression from prediabetes to type 2 diabetes with a 7–10% weight loss and manage cardiometabolic health for diabetic people with a ...
Tesofensine primarily acts as an appetite suppressant, [8] but possibly also acts by increasing resting energy expenditure. [9] A recent study showed that tesofensine modulates neuronal activity of the lateral hypothalamus, silencing GABAergic neurons, [8] a brain region involve on feeding. Phase II clinical trials for the treatment of obesity ...
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