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Haloperidol, sold under the brand name Haldol among others, is a typical antipsychotic medication. [9] Haloperidol is used in the treatment of schizophrenia , tics in Tourette syndrome , mania in bipolar disorder , delirium , agitation, acute psychosis , and hallucinations from alcohol withdrawal .
Haloperidol decanoate is provided in the form of 50 or 100 mg/mL oil solution of sesame oil and benzyl alcohol in ampoules or pre-filled syringes. [6] [7] [9] Its elimination half-life after multiple doses is 21 days. [10] [11] The medication is marketed in many countries throughout the world. [3] [12
The first LAI antipsychotics (often referred to as simply "LAIs") were the typical antipsychotics fluphenazine and haloperidol. [18] Both fluphenazile and haloperidol are formulated as decanoates, referring to the attachment of a decanoic acid group to the antipsychotic molecule. [18] These are then dissolved in an organic oil. [18]
Abilify (aripiprazole) – atypical antipsychotic used to treat schizophrenia, bipolar disorder, and irritability associated with autism; Adderall (mixed amphetamine salts) – a stimulant used to treat ADHD
HPP + is formed from haloperidol, and its dehydration product HPTP, by CYP3A enzymes in the liver. [ 1 ] [ 2 ] [ 4 ] The compound can cross the blood–brain barrier and has been detected in the brain following haloperidol administration in both animals and humans.
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The first description of haloperidol in the treatment of Tourette's was published by Seignot in 1961. [17] [18] The turning point came in 1965, when Arthur K. Shapiro—described as "the father of modern tic disorder research" [19] —treated a Tourette's patient with haloperidol. Shapiro and his wife, Elaine Shapiro, reported the treatment in ...