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The connecting peptide, or C-peptide, is a short 31-amino-acid polypeptide that connects insulin's A-chain to its B-chain in the proinsulin molecule. In the context of diabetes or hypoglycemia, a measurement of C-peptide blood serum levels can be used to distinguish between different conditions with similar clinical features.
This specific peptide sequence relates to bone turnover because it is the portion that is cleaved by osteoclasts during bone resorption, and its serum levels are therefore proportional to osteoclastic activity at the time the blood sample is drawn. [1] Serum levels in healthy patients not taking bisphosphonates tends to hover above 300 pg/mL.
Blood coagulation and the protein C anticoagulation pathway. Protein C is a major component in anticoagulation in the human body. It acts as a serine protease zymogen: APC proteolyses peptide bonds in activated Factor V and Factor VIII (Factor V a and Factor VIII a), and one of the amino acids in the bond is serine.
The C peptide is between the A and B chains of proinsulin. [7] The connection between the A chain and C peptide is much more stable than the junction between the C peptide and B chain, with alpha helical features being exhibited near the C peptide-A chain connection. [10] The C peptide-A chain junction occurs between residues 64 and 65 of ...
As a result, patients present symptoms of low blood glucose (hypoglycemia), which are improved by eating. The diagnosis of an insulinoma is usually made biochemically with low blood glucose, elevated insulin, proinsulin, and C-peptide levels, and confirmed by localizing the tumour with medical imaging or angiography. The definitive treatment is ...
Electrophoresis is a laboratory technique in which the blood serum (the fluid portion of the blood after the blood has clotted) is applied to either an acetate membrane soaked in a liquid buffer, [3] or to a buffered agarose gel matrix, or into liquid in a capillary tube, and exposed to an electric current to separate the serum protein ...
cathode-ray tube capillary refill time central retinal thickness certified respiratory therapist. CRTx: chemoradiotherapy: CS: caesarean section compartment syndrome culture sensitivity Churg–Strauss syndrome: C/S: Caesarean section: C&S: culture and sensitivity (antibiogram) CsA: cyclosporin A CSA: Controlled Substances Act: C-section ...
1361 56373 Ensembl ENSG00000080618 ENSMUSG00000021999 UniProt Q96IY4 Q9JHH6 RefSeq (mRNA) NM_016413 NM_001278541 NM_001872 NM_019775 RefSeq (protein) NP_001265470 NP_001863 NP_062749 Location (UCSC) Chr 13: 46.05 – 46.11 Mb Chr 14: 75.48 – 75.52 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Carboxypeptidase B2 (CPB2), also known as carboxypeptidase U (CPU), plasma ...