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Adipose tissue (also known as body fat or simply fat) is a loose connective tissue composed mostly of adipocytes. [ 1 ] [ 2 ] It also contains the stromal vascular fraction ( SVF ) of cells including preadipocytes , fibroblasts , vascular endothelial cells and a variety of immune cells such as adipose tissue macrophages .
Its primary function is thermoregulation. In addition to heat produced by shivering muscle, brown adipose tissue produces heat by non-shivering thermogenesis . The therapeutic targeting of brown fat for the treatment of human obesity is an active research field.
The marrow adipose tissue depot is poorly understood in terms of its physiologic function and relevance to bone health. Marrow adipose tissue expands in states of low bone density but additionally expands in the setting of obesity. [4] Marrow adipose tissue response to exercise approximates that of white adipose tissue.
Mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells or medicinal signaling cells, are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue).
Bone marrow adipose tissue (BMAT), sometimes referred to as marrow adipose tissue (MAT), is a type of fat deposit in bone marrow. It increases in states of low bone density, such as osteoporosis , [ 1 ] [ 2 ] anorexia nervosa / caloric restriction , [ 3 ] [ 4 ] skeletal unweighting such as that which occurs in space travel , [ 5 ] [ 6 ] and ...
PPARG knockout mice are devoid of adipose tissue, establishing PPARG as a master regulator of adipocyte differentiation. [ 12 ] PPARG increases insulin sensitivity by enhancing storage of fatty acids in fat cells (reducing lipotoxicity ), by enhancing adiponectin release from fat cells, by inducing FGF21 , [ 12 ] and by enhancing nicotinic acid ...
White adipose tissue or white fat is one of the two types of adipose tissue found in mammals. The other kind is brown adipose tissue. White adipose tissue is composed of monolocular adipocytes. In humans, the healthy amount of white adipose tissue varies with age, but composes between 6–25% of body weight in adult men and 14–35% in adult women.
In vitro studies on differentiation have used the pre-committed preadipocyte lineage, such as 3T3-L1 and 3T3-F442A cell line, or preadipocytes isolated from the stromal-vascular fraction of white adipose tissue. In vitro differentiation is a highly ordered process. Firstly, proliferating preadipocytes arrest growth usually by contact inhibition.