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Ankylosing spondylitis (AS) is a systemic rheumatic disease, meaning it affects the entire body. 1–2% of individuals with the HLA-B27 genotype develop the disease. [17] Tumor necrosis factor-alpha (TNF α) and interleukin 1 (IL-1) are also implicated in ankylosing spondylitis.
Microscopically visible ileal inflammation is seen in about 50% of people with spondyloarthritis and ankylosing spondylitis during ileocolonoscopy. [11] [4] There seems to be an immunological connection between the gut inflammation observed in Crohn's disease and ankylosing spondylitis. [12]
The term itself is an umbrella term characterizing a diverse disease family united by shared clinical and genetic features, such as the involvement of the axial skeleton. [2] The 2009 introduced term axial spondyloarthritis is a preferred term nowadays and substitutes the old term ankylosing spondylitis. [3]
Ankylosing spondylitis [25] Juvenile idiopathic arthritis [26] Still's disease [27] Psoriatic arthritis [28] Joint pain can also be a symptom of other diseases. In this case, the person may not have arthritis and instead have one of the following diseases: Psoriasis [29] Reactive arthritis [30] Ehlers–Danlos syndrome [31] Iron overload [32 ...
Among the genetic factors that may influence ankylosing spondylitis, the HLA-B27 gene accounts for about thirty percent of the overall genetic risk, per the National Library of Medicine. The ...
Ankylosing spondylitis (AS) is a form of arthritis that primarily affects the spine, although other joints can become involved. It causes inflammation of the spinal joints (vertebrae) that can lead to severe, chronic pain and discomfort.
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