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Micrograph of psammoma body in the centre of the field in a meningioma of brain. H&E stain. A psammoma body is a round collection of calcium, seen microscopically. The term is derived from Greek άμμος (ámmos) 'sand'.
Corpora arenacea (singular: corpus arenaceum, [1] also called brain sand or acervuli [2] [3] or psammoma bodies [4] or pineal concretions [4]) are calcified structures in the pineal gland and other areas of the brain such as the choroid plexus. Older organisms have numerous corpora arenacea, whose function, if any, is unknown.
Micrograph of a psammoma body in the centre of the field in a meningioma of brain. H&E stain. Histologically, meningioma cells are relatively uniform, with a tendency to encircle one another, forming whorls and psammoma bodies (laminated calcific concretions). [19] As such, they also have a tendency to calcify and are highly vascularized ...
Psammoma bodies are more frequent in low-grade serous carcinoma. Tp53 expression is assessed for mutations, overexpression or absence – common features of high-grade serous carcinomas. LGSCs are generally limited to micropapillary growth patterns, whereas HGSCs can exhibit admixed patterns.
Micrograph of uterine serous carcinoma demonstrating characteristic psammoma bodies and cilia. H&E stain. Characteristic discohesiveness of cells (like falling apart) around fibrovascular cores. The lesion is found in patients who present typically with abnormal or postmenopausal bleeding. [2]
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Characteristic Orphan Annie eye nuclear clearings (nuclei with uniform staining, which appear empty due to powdery chromatin and marginal micronucleoli) [12] and psammoma bodies on light microscopy. The former is useful in identifying the follicular variant of papillary thyroid carcinomas. [13]
A 2022 study looked at more than 2,500 people with a BMI (body mass index) of 30 or more or a BMI of 27 or more with at least one weight-related health condition that wasn’t diabetes.