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Russell bodies are inclusion bodies usually found in atypical plasma cells that become known as Mott cells. [1] Russell bodies are eosinophilic , homogeneous immunoglobulin (Ig)-containing inclusions usually found in cells undergoing excessive synthesis of Ig; the Russell body is characteristic of the distended endoplasmic reticulum .
Howell-Jolly body-like inclusions (HJBLi) Russell bodies are inclusions of immunoglobulin found in atypical plasma cells. Russell bodies clump together in large numbers displacing the cell nucleus to the edge, and the cell is then called a Mott cell. [12]
The tissue is filled with lymphocytes, plasma cells, mast cells, histiocytes, and eosinophils. It is not uncommon to see plasma cells with Russell bodies and Mott cell formation. Depending on length of symptoms, multinucleated giant cells and calcifications may be seen.
Plasma cells with Dutcher and Russell bodies (H&E stain, 100×, oil) Plasma cells are large lymphocytes with abundant cytoplasm and a characteristic appearance on light microscopy. They have basophilic cytoplasm and an eccentric nucleus with heterochromatin in a characteristic cartwheel or clock face arrangement.
Diagnostic characteristics are most commonly found in the granulomatous stage and are described as being plasma cells with birefringent inclusions, Russell bodies, pseudoepitheliomatous hyperplasia, and groups of large vacuolated histiocytes containing Klebsiella rhinoscleromatis (Mikulicz cells). [2]
Reactive lymphocyte surrounded by red blood cells. In immunology, reactive lymphocytes, variant lymphocytes, atypical lymphocytes, Downey cells or Türk cells are cytotoxic (CD8 +) lymphocytes that become large as a result of antigen stimulation. Typically, they can be more than 30 μm in diameter with varying size and shape.
Russell’s go-to Hallmark partner is Cindy Busby.The pair first worked together in UPtv’s 2016 holiday film, A Puppy for Christmas.They have since teamed for three Hallmark projects: 2020’s ...
Bizarre cells, which are multinucleated; Mott cells, containing multiple clustered cytoplasmic droplets or other inclusions (sometimes confused with Auer rods, commonly seen in myeloid blasts) Flame cells, having a fiery red cytoplasm [71] [72] Historically, the CD138 has been used to isolate myeloma cells for diagnostic purposes.