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Botox has been shown to be especially beneficial to reducing spasticity in the gastrocnemius (calf) muscle. This therapy can improve range of motion, reduce deformity, improve response to occupational and physical therapy, and delay the need for surgery. [5] Botulinum toxin type A injections have also shown advantages for upper extremities.
Botulinum toxin, or botulinum neurotoxin (commonly called botox), is a neurotoxic protein produced by the bacterium Clostridium botulinum and related species. [24] It prevents the release of the neurotransmitter acetylcholine from axon endings at the neuromuscular junction, thus causing flaccid paralysis. [25]
Right now, the standard of care for patients can include physical therapy, muscle relaxers, and Botox injections. They’re temporary, require routine clinical visits, and can get expensive.
If refractive to oral agents, spasticity may be treated with intrathecal baclofen therapy (IBT) when spasticity. IBT may also be used in patients with limited tolerance to other modalities. [24] Phenol injections can be used, or botulinum toxin [24] [18] [19] [25] injections into the muscle belly, to attempt to dampen the signals between nerve ...
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