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Antihypertensive agents are classified according to their mechanism of actions. The most common classes prescribed are diuretics, angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), calcium channel blockers (CCBs) and beta-blockers. Antihyperlipidemic agents most often prescribed are statins, ezetimibe and ...
The angiotensin II receptor blockers have differing potencies in relation to blood pressure control, with statistically differing effects at the maximal doses. [12] When used in clinical practice, the particular agent used may vary based on the degree of response required. [citation needed] Some of these drugs have a uricosuric effect. [13] [14]
The angiotensin receptor blockers (ARBs), also called angiotensin (AT1) receptor antagonists or sartans, are a group of antihypertensive drugs that act by blocking the effects of the hormone angiotensin II (Ang II) in the body, thereby lowering blood pressure.
Angiotensin II receptor type 1 (AT1) is a G q/11-coupled G protein-coupled receptor (GPCR) and the best characterized angiotensin receptor. It is encoded in humans by the AGTR1 gene. AT1 has vasopressor effects and regulates aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system.
Candesartan is an angiotensin receptor blocker used mainly for the treatment of high blood pressure and congestive heart failure. Candesartan has a very low maintenance dose . Like olmesartan , the metabolism of the drug is unusual as it is a cascading prodrug .
It is an angiotensin II receptor antagonist and works by blocking the effects of angiotensin II. [8] Valsartan was patented in 1990, and came into medical use in 1996. [10] It is available as a generic medication. [11] In 2022, it was the 117th most commonly prescribed medication in the United States, with more than 5 million prescriptions. [12 ...
Anemia may occur, due to inhibition of the renin–angiotensin system. [17] As with other angiotensin receptor blockers, losartan may injure the liver, although this effect appears to be rare. [18] Electrolyte imbalances may occur in people with kidney problems who take losartan. [3] Adverse outcomes do not differ by sex, age, or race. [3]
It is an angiotensin II receptor antagonist and works by blocking the effects of angiotensin II. [5] Irbesartan was patented in 1990, and approved for medical use in 1997. [11] It is available as a generic medication. [9] In 2022, it was the 200th most commonly prescribed medication in the United States, with more than 2 million prescriptions ...