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Protease inhibitors were the second class of antiretroviral drugs developed. The first members of this class, saquinavir, ritonavir, and indinavir, were approved in late 1995–1996. Within 2 years, annual deaths from AIDS in the United States fell from over 50,000 to approximately 18,000 [5] Prior to this the annual death rate had been ...
Proteasome inhibitor. Chemical structure of bortezomib, the first proteasome inhibitor approved for use. Proteasome inhibitors (INN stem –zomib) [1] are drugs that block the action of proteasomes, cellular complexes that break down proteins. They are being studied in the treatment of cancer; three are approved for use in treating multiple ...
P. Pepstatin. PMSF. Potato carboxypeptidase inhibitor. Protease inhibitor (pharmacology) Proteinase inhibitors in plants.
The catalytic residues (His41, Cys145) are shown as yellow sticks. Nirmatrelvir is an antiviral medication developed by Pfizer which acts as an orally active 3C-like protease inhibitor. [3][4][5][6][7] It is part of a nirmatrelvir/ritonavir combination used to treat COVID-19 and sold under the brand name Paxlovid. [8]
Pages in category "NS3/4A protease inhibitors" The following 18 pages are in this category, out of 18 total. This list may not reflect recent changes. A. Asunaprevir; B.
HIV protease inhibitors are peptide-like chemicals that competitively inhibit the action of the virus aspartyl protease. These drugs prevent proteolytic cleavage of HIV Gag and Pol polyproteins that include essential structural and enzymatic components of the virus. This prevents the conversion of HIV particles into their mature infectious form.
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