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Interleukin-1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other names, is a cytokine protein that in humans is encoded by the IL1B gene.
Cell stress could be due to infection, injury, ischemia, hypoxia, acidosis and complement lysis. The IL-33 precursor molecule acts in a similar way as a DAMP molecule. [20] Inflammatory responses in the absence of infection (such as ischemia) are only dependent on IL-1α signaling via the Interleukin-1 receptor (IL-1R), rather than TLRs signaling.
The crystal structures of IL1A and IL1B [9] have been solved, showing them to share the same 12-stranded beta-sheet structure as both the heparin binding growth factors and the Kunitz-type soybean trypsin inhibitors. [10] The beta-sheets are arranged in 4 similar lobes around a central axis, 8 strands forming an anti-parallel beta-barrel.
The protein encoded by this gene is a decoy receptor for certain cytokines that belongs to the interleukin-1 receptor family. This protein binds interleukin-1α (IL1A), interleukin-1β (IL1B), and interleukin 1 receptor antagonist (IL1Ra), preventing them from binding to their regular receptors and thereby inhibiting the transduction of their signaling.
Stress proteins can exhibit widely varied functions within a cell- both during normal life processes and in response to stress. For example, studies in Drosophila have indicated that when DNA encoding certain stress proteins exhibit mutation defects, the resulting cells have impaired or lost abilities such as normal mitotic division and ...
Interleukin-1 receptor (IL-1R) is a cytokine receptor which binds interleukin 1. [1] Two forms of the receptor exist. The type I receptor is primarily responsible for transmitting the inflammatory effects of interleukin-1 (IL-1) while type II receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding. [1]
Caspase-1 Zymogen. Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines interleukin 1β and interleukin 18 as well as the pyroptosis inducer Gasdermin D, into active mature peptides.
Probability density of stress S (red, top) and resistance R (blue, top), and of equality (m = R - S = 0, black, bottom). Distribution of stress S and strength R: all the (R, S) situations have a probability density (grey level surface). The area where the margin m = R - S is positive is the set of situation where the system is reliable (R > S).