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Zinc L-carnosine (beta-alanyl-L-histidinato zinc [1]) (N-(3-aminopropionyl)-L-histidinato zinc [2]), often simply called zinc carnosine, and also known as polaprezinc, [3] is a mucosal protective [4] [5] chelate compound of zinc and L-carnosine invented by Hamari Chemicals, Ltd. [6] [7] It is a quadridentate 1:1 complex of a polymeric nature. [6]
Carnosine (beta-alanyl-L-histidine) is a dipeptide molecule, made up of the amino acids beta-alanine and histidine. It is highly concentrated in muscle and brain tissues. [citation needed] Carnosine was discovered by Russian chemist Vladimir Gulevich. [1] Carnosine is naturally produced by the body in the liver [2] from beta-alanine and histidine.
It is a dimer, and hydrolyzes both carnosine and anserine, preferring dipeptides that have a histidine monomer in the C-terminus position. [ 11 ] [ 12 ] Tissue carnosinase is often considered a "nonspecific dipeptidase", [ 13 ] [ 15 ] based in part on its ability to hydrolyze a range of dipeptide substrates , including those belonging to ...
Carnosine (β-alanyl-L-histidine), and its topical prodrug formulation N-acetylcarnosine (NAC), is advertised (especially on the internet) to treat a range of ophthalmic disorders associated with oxidative stress, including age-related and diabetic cataracts. No convincing animal studies or masked clinical trials have been reported.
pimobendan – phosphodiesterase 3 inhibitor used to manage heart failure in dogs; pirlimycin – antimicrobial; ponazuril – anticoccidial; praziquantel – treatment of infestations of the tapeworms Dipylidium caninum, Taenia pisiformis, Echinococcus granulosus; prazosin – sympatholytic used in hypertension and abnormal muscle contractions
Dog treats are often given to pets as a reward or just to let them chew on a bone, which works their jaw muscles and helps keep their teeth clean. [67] Although dog treats carry high benefits for dogs' teeth, they can also be a source of problems like obesity when given excessively, especially human table scraps.
Granulomatous meningoencephalitis (GME) is an inflammatory disease of the central nervous system (CNS) of dogs and, rarely, cats.It is a form of meningoencephalitis.GME is likely second only to encephalitis caused by canine distemper virus as the most common cause of inflammatory disease of the canine CNS. [1]
The senior dog population consists of dogs that are over the age of seven for most dog breeds, [1] though in general large and giant breed dogs tend to reach this life stage earlier when compared to smaller breed dogs. Senior dog foods contain nutrients and characteristics that are used to improve the health of the aging dog.