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Chondroblastoma is a rare, benign, locally aggressive bone tumor that typically affects the epiphyses or apophyses of long bones. [ 1 ] [ 2 ] It is thought to arise from an outgrowth of immature cartilage cells ( chondroblasts ) from secondary ossification centers , originating from the epiphyseal plate or some remnant of it.
A number of tumors have giant cells, but are not true benign giant-cell tumors. These include aneurysmal bone cyst, chondroblastoma, simple bone cyst, osteoid osteoma, osteoblastoma, osteosarcoma, giant-cell reparative granuloma, Giant-cell tumor of the tendon sheath and brown tumor of hyperparathyroidism. [citation needed]
Somatic mutations mostly in the H3F3B gene are associated with chondroblastoma, [8] but some are associated with mutations in H3F3A. [5] A rare de novo germline mutation of the H3F3B gene (A30P) has been linked to a syndrome with a range of developmental and behavioral abnormalities including microcephaly, mild strabismus, seizure disorder, autistic continuum, hypothyroidism, global ...
M9230/0 Chondroblastoma, NOS Chondromatous giant cell tumor; Codman tumor; M9230/3 Chondroblastoma, malignant M9231/3 Myxoid chondrosarcoma M9240/3 Mesenchymal chondrosarcoma M9241/0 Chondromyxoid fibroma M9242/3 Clear cell chondrosarcoma M9243/3 Dedifferentiated chondrosarcoma
This page was last edited on 1 December 2020, at 08:18 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
Within adults and developing adults, most chondroblasts are located in the perichondrium. This is a thin layer of connective tissue which protects cartilage and is where chondroblasts help to expand cartilage size whenever prompted to by hormones such as GH, TH, and glycosaminoglycans. [2]
Chondroblastoma [2] Chondromyxoid fibroma [2] Osteochondromyxoma [2] Locally aggressive: Chondromatosis [2] Atypical cartilaginous tumor [2] Cancerous (chondrosarcoma) Conventional chondrosarcoma grade I-III [2] Clear cell chondrosarcoma [2] Mesenchymal chondrosarcoma [2] Dedifferentiated chondrosarcoma [2]
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