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Nucleoside analog reverse-transcriptase inhibitors (NARTIs or NRTIs) compose the first class of antiretroviral drugs developed. In order to be incorporated into the viral DNA, NRTIs must be activated in the cell by the addition of three phosphate groups to their deoxyribose moiety, to form NRTI triphosphates.
Emtricitabine/tenofovir is generally well tolerated. Some of its side effects include: [7] Rare: lactic acidosis, liver dysfunction, worsening of hepatitis B infection; Common: headache, abdominal pain, decreased weight, nausea, diarrhea, and decreased bone density
Severe side effects include enlargement of the liver, high blood lactate levels, and liver inflammation if the medication is stopped. [6] While there appears to be no harm from use during pregnancy, this use has not been well studied. [1] Entecavir is in the nucleoside reverse transcriptase inhibitors (NRTIs) family of medications.
Emtricitabine (commonly called FTC, systematic name 2',3'-dideoxy-5-fluoro-3'-thiacytidine [2]), with trade name Emtriva (formerly Coviracil), is a nucleoside reverse-transcriptase inhibitor (NRTI) for the prevention and treatment of HIV infection in adults and children.
Lamivudine is a nucleoside reverse transcriptase inhibitor and works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase. [1] Lamivudine was patented in 1995 and approved for use in the United States in 1995. [8] [9] It is on the World Health Organization's List of Essential Medicines. [10] It is available as a generic ...
Abacavir is a nucleoside reverse transcriptase inhibitor that inhibits viral replication. It is a guanosine analogue that is phosphorylated to carbovir triphosphate (CBV-TP). CBV-TP competes with the viral molecules and is incorporated into the viral DNA.
Reverse-transcriptase inhibitor: Clinical data; ... and 300 mg lamivudine, a nucleoside analogue reverse transcriptase ... The most common serious side effects are ...
Nucleoside reverse-transcriptase inhibitors (NRTI) and nucleotide reverse-transcriptase inhibitors (NtRTI) are nucleoside and nucleotide analogues which inhibit reverse transcription. HIV is an RNA virus, so it can not be integrated into the DNA in the nucleus of the human cell unless it is first "reverse" transcribed into DNA.