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  2. Genetically modified animal - Wikipedia

    en.wikipedia.org/wiki/Genetically_modified_animal

    Principles such as animal integrity, naturalness, risk identification and animal welfare are examples of ethically important factors that must be taken into consideration, and they also influence public perception and regulatory decisions by authorities. [196] The utility of extrapolating animal data to humans has been questioned.

  3. Genetic engineering techniques - Wikipedia

    en.wikipedia.org/wiki/Genetic_engineering_techniques

    Genetic engineering techniques allow the modification of animal and plant genomes. Techniques have been devised to insert, delete, and modify DNA at multiple levels, ranging from a specific base pair in a specific gene to entire genes. There are a number of steps that are followed before a genetically modified organism (GMO) is created.

  4. Knockout mouse - Wikipedia

    en.wikipedia.org/wiki/Knockout_mouse

    Examples of research in which knockout mice have been useful include studying and modeling different kinds of cancer, obesity, heart disease, diabetes, arthritis, substance abuse, anxiety, aging and Parkinson's disease. Knockout mice also offer a biological and scientific context in which drugs and other therapies can be developed and tested.

  5. Genetically modified mouse - Wikipedia

    en.wikipedia.org/wiki/Genetically_modified_mouse

    A genetically modified mouse, genetically engineered mouse model (GEMM) [1] or transgenic mouse is a mouse (Mus musculus) that has had its genome altered through the use of genetic engineering techniques. Genetically modified mice are commonly used for research or as animal models of human diseases and are also used for research on genes.

  6. Genetic engineering - Wikipedia

    en.wikipedia.org/wiki/Genetic_engineering

    This is an accepted version of this page This is the latest accepted revision, reviewed on 2 February 2025. Manipulation of an organism's genome For a non-technical introduction to the topic of genetics, see Introduction to genetics. For the song by Orchestral Manoeuvres in the Dark, see Genetic Engineering (song). For the Montreal hardcore band, see Genetic Control. Part of a series on ...

  7. Genetically modified organism - Wikipedia

    en.wikipedia.org/wiki/Genetically_modified_organism

    A genetically modified organism (GMO) is any organism whose genetic material has been altered using genetic engineering techniques.The exact definition of a genetically modified organism and what constitutes genetic engineering varies, with the most common being an organism altered in a way that "does not occur naturally by mating and/or natural recombination". [1]

  8. Genetically modified mammal - Wikipedia

    en.wikipedia.org/wiki/Genetically_modified_mammal

    Genetically modified mammals are mammals that have been genetically engineered.They are an important category of genetically modified organisms.The majority of research involving genetically modified mammals involves mice with attempts to produce knockout animals in other mammalian species limited by the inability to derive and stably culture embryonic stem cells.

  9. Gene knockout - Wikipedia

    en.wikipedia.org/wiki/Gene_knockout

    This technique can be used in a variety of organisms, including bacteria, yeast, plants, and animals, and it allows scientists to study the function of specific genes by observing the effects of their absence. CRISPR-based gene knockout is a powerful tool for understanding the genetic basis of disease and for developing new therapies.