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Dr Hayley Luxton, senior research impact manager at Prostate Cancer UK, said: “Multiparametric MRI (mpMRI) scans have transformed how we diagnose prostate cancer, giving men a more accurate ...
In a 2015 articles in the Journal of Urology, Thompson reported multi-parametric MRI detection of significant prostate cancer had sensitivity of 96%, specificity of 36%, negative predictive value and positive predictive values of 92% and 52%; when PI-RADS was incorporated into a multivariate analysis (PSA, digital rectal exam, prostate volume ...
Removing the final step – which involves patients being injected with contrast dye – could slash costs and time, as well an increasing availability.
Recently, a Multiparametric imaging radiomic framework termed MPRAD for extraction of radiomic features from high dimensional datasets was developed. [64] The Multiparametric Radiomics was tested on two different organs and diseases; breast cancer and cerebrovascular accidents in brain, commonly referred to as stroke.
Prostate cancer antigen 3 is a urine test that detects the overexpression of the PCA3 gene, an indicator of prostate cancer. [32] [46] [47] [44] ConfirmMDx is performed on tissue taken during a prostate biopsy. The test identifies men with clinically significant prostate cancer who would benefit from further testing and treatment.
In fact, a side-by-side comparison of TRUS versus MRI-guided targeted biopsy that was conducted as a prospective, investigator-blinded study demonstrated that MRI-guided biopsy improved detection of significant prostate cancer by 17.7%, and decreased the diagnosis of insignificant or low-risk disease by 89.4%. [12]
MRI is the investigation of choice in the preoperative staging of rectal and prostate cancer and has a role in the diagnosis, staging, and follow-up of other tumors, [28] as well as for determining areas of tissue for sampling in biobanking. [29] [30]
Prostate cancer is a major topic of ongoing research. From 2016–2020, over $1.26 billion was invested in prostate cancer research, representing around 5% of global cancer research funds. [122] This places prostate cancer 10th among 18 common cancer types in funding per cancer death, and 9th in funding per disability-adjusted life year lost. [123]