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Diphenoxylate/atropine, also known as co-phenotrope and sold under the brand name Lomotil among others, is used to treat diarrhea. [2] [3] It is a fixed-dose combination of the medications diphenoxylate, as the hydrochloride, an antidiarrheal; and atropine, as the sulfate, an anticholinergic. [1] It is taken by mouth. [2] Onset is typically ...
Decreasing intestinal motility prolongs the transit time of food content through the digestive tract, which allows for more fluid absorption; thereby alleviating diarrhea symptoms and improving stool consistency and frequency. [4] Unlike other opiates, loperamide does not cross the blood brain barrier, so there is minimal risk for abuse. [5]
Drugs such as morphine or codeine can be used to relieve diarrhoea this way. A notable opioid for the purpose of relief of diarrhoea is loperamide which is only an agonist of the μ opioid receptors in the large intestine and does not have opioid affects in the central nervous system as it doesn't cross the blood–brain barrier in significant ...
Patients with bacterial overgrowth typically develop symptoms which may include nausea, bloating, vomiting, diarrhea, malnutrition, weight loss, and malabsorption [2] by various mechanisms. The diagnosis of bacterial overgrowth is made by a number of techniques, with the gold standard [ 3 ] being an aspirate from the jejunum that grows in ...
The medication provides relief from nausea by blocking D 2 receptors in the chemoreceptor trigger zone and from gastrointestinal symptoms by blocking D 2 receptors in the gut. [ 20 ] [ 2 ] It blocks D 2 receptors in the lactotrophs of the anterior pituitary gland increasing release of prolactin which in turn increases lactation .
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