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Dementia with Lewy bodies (DLB) is a type of dementia, a group of diseases involving progressive neurodegeneration of the central nervous system. [11] It is one of the two Lewy body dementias, along with Parkinson's disease dementia.
Dementia with Lewy bodies and Parkinson's disease dementia are similar in many ways, suggesting there may be a common pathophysiological mechanism, with PDD and DLB at opposite ends of a Lewy body disease spectrum, [2] and a shared component of protein deposits in Lewy bodies and Lewy neurites. [17]
Lewy neurites are abnormal neurites in diseased neurons, containing granular material and abnormal α-synuclein filaments similar to those found in Lewy bodies. [20] Like Lewy bodies, Lewy neurites are a feature of α-synucleinopathies such as dementia with Lewy bodies, Parkinson's disease, and multiple system atrophy. [21]
Dementia with Lewy bodies is the second most common type of dementia after Alzheimer’s disease, comprising between 15-20% of all dementia diagnoses. Also known as Lewy body dementia, it is ...
Dementia; Dermatillomania; Dermatomyositis; Developmental coordination disorder; Diabetic neuropathy; Disc herniation; Diffuse sclerosis; Diplopia; Disorders of consciousness; Distal hereditary motor neuropathy type V; Distal spinal muscular atrophy type 1; Distal spinal muscular atrophy type 2; Dizziness; Down syndrome; Dravet syndrome ...
The DNA repair function of alpha-synuclein appears to be compromised in Lewy body inclusion bearing neurons, and this may trigger cell death. Study of synucleinopathy mouse models of Parkinson's disease indicates that alpha-synuclein pathogenesis is associated with increased DNA damage and activation of the DNA damage response.
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