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The five main classes in the Vaughan Williams classification of antiarrhythmic agents are: Class I agents interfere with the sodium (Na +) channel. Class II agents are anti-sympathetic nervous system agents. Most agents in this class are beta blockers. Class III agents affect potassium (K +) efflux. Class IV agents affect calcium channels and ...
It is a sodium channel blocker and is classified as a Class 1a anti-arrhythmic agent. [3] [4] Disopyramide has a negative inotropic effect on the ventricular myocardium, significantly decreasing the contractility. [5] [6] Disopyramide also has general anticholinergic effects which contribute to unwanted adverse effects. Disopyramide is ...
Sparteine is a class 1a antiarrhythmic agent and sodium channel blocker. It is an alkaloid and can be extracted from scotch broom.It is the predominant alkaloid in Lupinus mutabilis, and is thought to chelate the bivalent metals calcium and magnesium.
Representation of the ion channel opening/closing that antiarrhythmics act upon . Antiarrhythmics are broad class of drugs that are used treat heart rhythm irregularities. [16] Utilizing the Vaughan-Williams (VW) system, antiarrhymic drugs are classified into four main classes based on their mechanism of action. Class I antiarrhymics lead to ...
Of the sodium channel blocking antiarrhythmic agents (the class I antiarrhythmic agents), the class Ic agents have the most potent sodium channel blocking effects. Class Ic agents are indicated for supraventricular arrhythmias (i.e. atrial fibrillation) and as a last line treatment for refractory life-threatening ventricular tachycardia or ...
Ajmaline (also known by trade names Gilurytmal, Ritmos, and Aritmina) is an alkaloid that is classified as a 1-A antiarrhythmic agent.It is often used to induce arrhythmic contraction in patients suspected of having Brugada syndrome.
Quinidine is a class IA antiarrhythmic agent used to treat heart rhythm disturbances. [1] It is a diastereomer of antimalarial agent quinine, [2] originally derived from the bark of the cinchona tree. The drug causes increased action potential duration, as well as a prolonged QT interval. As of 2019, its IV formulation is no longer being ...
Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of cardiac dysrhythmias. [4] This includes ventricular tachycardia, ventricular fibrillation, and wide complex tachycardia, atrial fibrillation, and paroxysmal supraventricular tachycardia. [4]