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Lighter Side. Politics. Science & Tech. Sports. Weather. 24/7 Help. ... Insulin resistance without treatment with lifestyle changes or medications may lead to conditions such as: Prediabetes.
Metformin is a prescription medication used to treat high blood sugar in those with type 2 diabetes who are resistant to the effects of insulin. It’s in a class of drugs known as biguanides.
Drugs used in diabetes treat types of diabetes mellitus by decreasing glucose levels in the blood.With the exception of insulin, most GLP-1 receptor agonists (liraglutide, exenatide, and others), and pramlintide, all diabetes medications are administered orally and are thus called oral hypoglycemic agents or oral antihyperglycemic agents.
Metformin has indirect antiandrogenic effects in women with insulin resistance, such as those with PCOS, due to its beneficial effects on insulin sensitivity. [124] It may reduce testosterone levels in such women by as much as 50%. [124]
Side effects include weight gain and hypoglycemia. While the potential for hypoglycemia is less than for those on sulfonylureas, [citation needed] it is still a serious potential side effect that can be life-threatening. Patients on this medication should know the signs and symptoms of hypoglycemia and appropriate management.
“Effects on insulin signaling are likely involved,” Alan says. “Metformin restores insulin sensitivity, and this has been linked to weight loss and an increase in health span. There are ...
The primary treatment for insulin resistance is exercise and weight loss. [59] Both metformin and thiazolidinediones improve insulin sensitivity. Metformin is approved for prediabetes and type 2 diabetes and has become one of the more commonly prescribed medications for insulin resistance. [60]
Diazoxide is used as a vasodilator in the treatment of acute hypertension or malignant hypertension. [7]Diazoxide also inhibits the secretion of insulin by opening ATP-sensitive potassium channel of beta cells of the pancreas; thus, it is used to counter hypoglycemia in disease states such as insulinoma (a tumor producing insulin) [8] or congenital hyperinsulinism.