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A meta-analysis of such expression profiles was performed to derive novel conclusions and to validate the known findings. [148] Meta-analysis of whole genome sequencing studies provides an attractive solution to the problem of collecting large sample sizes for discovering rare variants associated with complex phenotypes.
"Meta" is Greek for "beyond"; "narrative" is a story that is characterized by its telling (it is communicated somehow). [6]Although first used earlier in the 20th century, the term was brought into prominence by Jean-François Lyotard in 1979, with his claim that the postmodern was characterized precisely by mistrust of the "grand narratives" (such as ideas about Progress, Enlightenment ...
A meta-analysis with some or all studies having more than two arms is called network meta-analysis, indirect meta-analysis, or a multiple treatment comparison. Despite also being an umbrella term, meta-analysis sometimes implies that all included studies have strictly two arms each—same two treatments in all trials—to distinguish itself ...
For example, if both p-values are around 0.10, or if one is around 0.04 and one is around 0.25, the meta-analysis p-value is around 0.05. In statistics , Fisher's method , [ 1 ] [ 2 ] also known as Fisher's combined probability test , is a technique for data fusion or " meta-analysis " (analysis of analyses).
Examples of such works are scientific reviews and meta-analyses. These and related practices face various challenges and are a subject of metascience. Various issues with included or available studies such as, for example, heterogeneity of methods used may lead to faulty conclusions of the meta-analysis. [115]
A research proposal is a document proposing a research project, generally in the sciences or academia, and generally constitutes a request for sponsorship of that research. [1] Proposals are evaluated on the cost and potential impact of the proposed research, and on the soundness of the proposed plan for carrying it out. [ 2 ]
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In an IPD meta-analysis, patient-level data from multiple studies or settings are combined to address a certain research question. IPD meta-analyses tend to be common for large-scale and international projects, and they are less limited than aggregate data (AD) meta-analyses in terms of the availability and quality of data they can use. [2]