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Mepyramine, also known as pyrilamine, is a first-generation antihistamine, targeting the H 1 receptor as an inverse agonist. [1] Mepyramine rapidly permeates the brain, often causing drowsiness. [2] It is often sold as a maleate salt, pyrilamine maleate.
Box of Midol, 2023 Midol advertisement, 1960. Midol is a brand of over-the-counter analgesic drugs marketed for menstrual cramping and other effects related to premenstrual syndrome and menstruation.
Pheniramine (trade name Avil among others) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria.It has relatively strong sedative effects, and may sometimes be used off-label as an over-the-counter sleeping pill in a similar manner to other sedating antihistamines such as diphenhydramine.
In July 1975, the J. B. Williams Co. began marketing Sominex 2. [37] On November 24, 1975, Attorney General Evelle J. Younger filed suit on behalf of the State of California against Williams Co., stating that the product did not warn against use by pregnant or nursing women or persons with asthma or COPD, nor did it notify consumers that it should not be used in conjunction with alcohol. [38]
The first-generation sedating antihistamines diphenhydramine, doxepin, doxylamine, and pyrilamine are the most widely used medications in the world for preventing and treating insomnia. [6] As of 2004, doxylamine and diphenhydramine, which are both over-the-counter medications, were the agents most commonly used to treat short-term insomnia. [11]
The maleate ion is the ionized form of maleic acid. ... e.g. carfenazine, chlorpheniramine, pyrilamine, methylergonovine, and thiethylperazine. [10] See also