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2,4-Dinitrophenol (DNP) is a very strong thermogenic drug used for fat loss which produces a dose-dependent increase in body temperature, to the point where it can induce death by hyperthermia. It works as a mitochondrial oxidative phosphorylation uncoupler, disrupting the mitochondrial electron transport chain .
Medications for common conditions can increase patients' sensitivity to heat by impairing the body's response to high temperatures, including the ability to sweat and the rate of blood flow.
Simplified control circuit of human thermoregulation. [8]The core temperature of a human is regulated and stabilized primarily by the hypothalamus, a region of the brain linking the endocrine system to the nervous system, [9] and more specifically by the anterior hypothalamic nucleus and the adjacent preoptic area regions of the hypothalamus.
In humans, hyperthermia is defined as a temperature greater than 37.5–38.3 °C (99.5–100.9 °F), depending on the reference used, that occurs without a change in the body's temperature set point. [3] [10] The normal human body temperature can be as high as 37.7 °C (99.9 °F) in the late afternoon. [2]
Your muscles contract to increase your body’s heat production and raise your temperature. “Shivering is very expensive because it involves burning energy,” says Dr. Romanovsky.
The human body has two methods of thermogenesis, which produces heat to raise the core body temperature. The first is shivering, which occurs in an unclothed person when the ambient air temperature is under 25 °C (77 °F) [dubious – discuss]. [18] It is limited by the amount of glycogen available in the body. [5]
Normal body temperature is around 37°C (98.6°F), and hypothermia sets in when the core body temperature gets lower than 35 °C (95 °F). [2] Usually caused by prolonged exposure to cold temperatures, hypothermia is usually treated by methods that attempt to raise the body temperature back to a normal range. [3]
Normal human body temperature (normothermia, euthermia) is the typical temperature range found in humans.The normal human body temperature range is typically stated as 36.5–37.5 °C (97.7–99.5 °F).