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Inner ear regeneration is the biological process by which the hair cells and supporting cells (i.e. Hensen's cells and Deiters cells) of the ear proliferate (cell proliferation) and regrow after hair cell injury. This process depends on communication between supporting cells and the brain.
[5] [6] Furthermore, Hensen's cells are also able to regenerate the damaged hair cells in some vertebrates; they undergo phagocytosis to eject the dead or injured hair cells, and reproduce both new hair cells and supporting cells into the cell cycle. One of the reasons is that the supporting cells are differentiated by the embryonic hair cells ...
The cell cycle inhibitor p27kip1 has also been found to encourage regrowth of cochlear hair cells in mice following genetic deletion or knock down with siRNA targeting p27. [36] [37] Research on hair cell regeneration may bring us closer to clinical treatment for human hearing loss caused by hair cell damage or death.
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Hearing: Cochlear duct: fluid waves in the endolymph of the cochlear duct stimulate the receptor cells, which in turn translate their movement into nerve impulses that the brain perceives as sound. Balance: Semicircular canals: angular acceleration of the endolymph in the semicircular canals stimulate the vestibular receptors of the endolymph.
The outer hair cells, instead, mainly 'receive' neural input from the brain, which influences their motility as part of the cochlea's mechanical "pre-amplifier". The input to the OHC is from the olivary body via the medial olivocochlear bundle. The cochlear duct is almost as complex on its own as the ear itself.
Pictures G-N show the tip links connecting the stereocilia. Tip links are extracellular filaments that connect stereocilia to each other or to the kinocilium in the hair cells of the inner ear . [ 1 ] [ 2 ] Mechanotransduction is thought to occur at the site of the tip links, which connect to spring-gated ion channels. [ 3 ]
These cochlear supporting cells include a somatic part, with its cupula, and a phalangeal process, which links the Deiters soma to the reticular lamina. The part of the phalanx which is included in the reticular lamina is the apex of the phalanx (phalangeal apex). The cells are named for neuroanatomist Otto Deiters.
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