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Sepsis is defined as SIRS in response to an infectious process. [48] Severe sepsis is defined as sepsis with sepsis-induced organ dysfunction or tissue hypoperfusion (manifesting as hypotension, elevated lactate, or decreased urine output). Severe sepsis is an infectious disease state associated with multiple organ dysfunction syndrome (MODS) [9]
Septic shock is a result of a systemic response to infection or multiple infectious causes. The precipitating infections that may lead to septic shock if severe enough include but are not limited to appendicitis, pneumonia, bacteremia, diverticulitis, pyelonephritis, meningitis, pancreatitis, necrotizing fasciitis, MRSA and mesenteric ischemia.
Many patients die due to sepsis; survivors are left with permanent scarring and disfigurement. [6] [7] Noma neonatorum is a severe infection affecting very young or newborn children in impoverished environments. A gangrenous infection spreads across the oral, nasal, and/or anal areas, and is frequently fatal.
C. canimorsus caused acute kidney failure due to sepsis in a man whose open hand wound was licked by his dog. [66] A 68-year-old man died from sepsis and necrotizing fasciitis after a wound was licked by his dog. [67] A patient with a perforated eardrum developed meningitis after his dog passed on a Pasteurella multocida infection by licking ...
Infection usually begins in the mouth or nose and enters the central nervous system via the eyes. [ 5 ] If the fungal infection begins in the nose or sinus and extends to brain, symptoms and signs may include one-sided eye pain or headache , and may be accompanied by pain in the face, numbness, fever , loss of smell , a blocked nose or runny nose .
In animals, they normally live in the small spaces between the teeth and gums, causing infection only when they can multiply freely in anoxic environments. An affected human often has recently had dental work , poor oral hygiene , periodontal disease , radiation therapy , or trauma (broken jaw) causing local tissue damage to the oral mucosa ...
E.coli bacteremia is usually the result of a urinary tract infection. Other organisms that can cause community-acquired bacteremia include Pseudomonas aeruginosa, Klebsiella pneumoniae, and Proteus mirabilis. Salmonella infection, despite mainly only resulting in gastroenteritis in the developed world, is a common cause of bacteremia in Africa ...
[1] [2] A species of considerable medical importance, P. aeruginosa is a multidrug resistant pathogen recognized for its ubiquity, its intrinsically advanced antibiotic resistance mechanisms, and its association with serious illnesses – hospital-acquired infections such as ventilator-associated pneumonia and various sepsis syndromes.