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  2. Management of Crohn's disease - Wikipedia

    en.wikipedia.org/wiki/Management_of_Crohn's_disease

    Adalimumab, like infliximab, is an antibody that targets tumor necrosis factor. [18] It has been shown to reduce the signs and symptoms of, and is approved for treatment of, moderate to severe Crohn's disease in adults who have not responded well to conventional treatments and who have lost response to or are unable to tolerate infliximab. [19]

  3. Infliximab - Wikipedia

    en.wikipedia.org/wiki/Infliximab

    Infliximab, a chimeric monoclonal antibody, sold under the brand name Remicade among others, is a medication used to treat a number of autoimmune diseases. This includes Crohn's disease , ulcerative colitis , rheumatoid arthritis , ankylosing spondylitis , psoriasis , psoriatic arthritis , and Behçet's disease . [ 23 ]

  4. TNF inhibitor - Wikipedia

    en.wikipedia.org/wiki/TNF_inhibitor

    A TNF inhibitor is a pharmaceutical drug that suppresses the physiologic response to tumor necrosis factor (TNF), which is part of the inflammatory response.TNF is involved in autoimmune and immune-mediated disorders such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, psoriasis, hidradenitis suppurativa and refractory asthma, so TNF inhibitors may be used in their ...

  5. Management of ulcerative colitis - Wikipedia

    en.wikipedia.org/wiki/Management_of_ulcerative...

    Patients on high dose sulfasalazine require folic supplementation (1 mg/day) because it inhibits folate absorption. If oral Mesalazine is still not working, prednisone is often given, starting at 40–60 mg/day. Prednisone often takes effect within 10–14 days. The dose should then be tapered by about 5 mg/week until it can be stopped altogether.

  6. Therapeutic drug monitoring - Wikipedia

    en.wikipedia.org/wiki/Therapeutic_drug_monitoring

    If the observed concentration is plausible but far from the suitable level, determine how to adjust the dosage to drive the concentration curve close to target. Several approaches exist for this, from the easiest “rule of three” to sophisticated computer-assisted calculations implementing Bayesian inference algorithms based on population ...

  7. Merck Manual of Diagnosis and Therapy - Wikipedia

    en.wikipedia.org/wiki/Merck_Manual_of_Diagnosis...

    The first edition of The Merck Manual was published in 1899 by Merck & Co., Inc. for physicians and pharmacists and was titled Merck's Manual of the Materia Medica. [6] [7] The 192 page book which sold for US $1.00, was divided into three sections, Part I ("Materia Medica") was an alphabetical listing of all known compounds thought to be of therapeutic value with uses and doses; Part II ...

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