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Because the receptor gene is expressed in several forms, it has many different (pleiotropic) effects in different parts of the body. When glucocorticoids bind to GR, its primary mechanism of action is the regulation of gene transcription. [5] [6] The unbound receptor resides in the cytosol of the cell. After the receptor is bound to ...
Annexin is a common name for a group of cellular proteins.They are mostly found in eukaryotic organisms (animals, plants and fungi). In humans, the annexins are found inside the cell.
In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.
In bioinformatics, the general feature format (gene-finding format, generic feature format, GFF) is a file format used for describing genes and other features of DNA, RNA and protein sequences. GFF Versions
301 16952 Ensembl ENSG00000135046 ENSMUSG00000024659 UniProt P04083 Q5T3N0 P10107 RefSeq (mRNA) NM_000700 NM_010730 RefSeq (protein) NP_000691 NP_034860 Location (UCSC) Chr 9: 73.15 – 73.17 Mb Chr 19: 20.35 – 20.37 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Annexin A1, also known as lipocortin I, is a protein that is encoded by the ANXA1 gene in humans. Function Annexin A1 ...
The goal is to normalize the production of 21-hydroxylase, the enzyme encoded by CYP21A2. Providing a working copy of this gene may improve adrenal hormone synthesis and subsequently normalize cortisol and aldosterone production. [253] Currently, gene replacement therapy for CAH is still at an early stage of research and development.
This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucocorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors ( serpins ).
Immediate early genes (IEGs) are genes which are activated transiently and rapidly in response to a wide variety of cellular stimuli. They represent a standing response mechanism that is activated at the transcription level in the first round of response to stimuli, before any new proteins are synthesized.