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Collagen alpha-1(IV) chain (COL4A1) is a protein that in humans is encoded by the COL4A1 gene on chromosome 13. [ 5 ] [ 6 ] It is ubiquitously expressed in many tissues and cell types. [ 7 ] COL4A1 is a subunit of the type IV collagen and plays a role in angiogenesis . [ 8 ]
Collagen IV is the more common usage, as opposed to the older terminology of "type-IV collagen". [citation needed] Collagen IV exists in all metazoan phyla, to whom they served as an evolutionary stepping stone to multicellularity. [1] There are six human genes associated with it: [2] COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6
Autosomal dominant porencephaly type I is caused by mutations in a gene called COL4A1, located at 13q34 (band 34 on the long arm of chromosome 13). These mutations are inherited in an autosomal dominant pattern. COL4A1 codes for a form of collagen, collagen type IV, which is an important element in the construction of the vascular basement ...
Collagen is a complex hierarchical material with mechanical properties that vary significantly across different scales. On the molecular scale, atomistic and course-grained modeling simulations, as well as numerous experimental methods, have led to several estimates of the Young's modulus of collagen at the molecular level.
In biology, the extracellular matrix (ECM), [1] [2] also called intercellular matrix (ICM), is a network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells.
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