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Collagen alpha-1(IV) chain (COL4A1) is a protein that in humans is encoded by the COL4A1 gene on chromosome 13. [ 5 ] [ 6 ] It is ubiquitously expressed in many tissues and cell types. [ 7 ] COL4A1 is a subunit of the type IV collagen and plays a role in angiogenesis . [ 8 ]
Collagen IV is the more common usage, as opposed to the older terminology of "type-IV collagen". [citation needed] Collagen IV exists in all metazoan phyla, to whom they served as an evolutionary stepping stone to multicellularity. [1] There are six human genes associated with it: [2] COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6
This syndrome is caused by mutations in the COL4A1 gene, on the chromosome 13q34, this gene provides instructions for making one of the components necessary for the formation of a protein called type IV collagen, this protein is one of the main components for basement membranes throughout the body.
12829 Ensembl ENSG00000081052 ENSMUSG00000067158 UniProt P53420 Q9QZR9 RefSeq (mRNA) NM_000092 NM_007735 RefSeq (protein) NP_000083 NP_031761 Location (UCSC) Chr 2: 227 – 227.16 Mb Chr 1: 82.43 – 82.56 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Collagen alpha-4(IV) chain is a protein that in humans is encoded by the COL4A4 gene. This gene encodes one of the six subunits of ...
Collagen is the most abundant protein in the human body (around 30 percent of protein in our bodies to be exact). Long story short, we need collagen to live because it is a building block for ...
Collagen is a vital protein in skin, hair, nails, and other tissues. Its production decreases with age and factors like sun damage and smoking. Collagen supplements, derived from sources like fish and cattle, are marketed to improve skin, hair, and nails. Studies show some skin benefits, but these supplements often contain other beneficial ...