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In biochemistry, the Luebering–Rapoport pathway (also called the Luebering–Rapoport shunt) is a metabolic pathway in mature erythrocytes involving the formation of 2,3-bisphosphoglycerate (2,3-BPG), which regulates oxygen release from hemoglobin and delivery to tissues. 2,3-BPG, the reaction product of the Luebering–Rapoport pathway was first described and isolated in 1925 by the ...
The normal glycolytic pathway generates 1,3-BPG, which may be dephosphorylated by phosphoglycerate kinase (PGK), generating ATP, or it may be shunted into the Luebering-Rapoport pathway, where bisphosphoglycerate mutase catalyzes the transfer of a phosphoryl group from C1 to C2 of 1,3-BPG, giving 2,3-BPG. 2,3-BPG, the most concentrated organophosphate in the erythrocyte, forms 3-PG by the ...
This reaction is a shortcut in the Luebering-Rapoport pathway. References External links. 2,3-bisphosphoglycerate+3-phosphatase at the U.S ...
He described the role of the 2,3-bisphosphoglycerate for the anaerobic production of energy in the erythrocytes (Luebering-Rapoport pathway). Jane Luebering was a technical assistant of Rapoport. Rapoport detected the eminent importance of the ATP concentration for the survivability of the erythrocytes.
The level of 2,3-bisphosphoglycerate is elevated: 1,3-bisphosphoglycerate, a precursor of phosphoenolpyruvate which is the substrate for Pyruvate kinase, is increased and so the Luebering-Rapoport pathway is overactivated. This led to a rightward shift in the oxygen dissociation curve of hemoglobin (i.e. it decreases the hemoglobin affinity for ...
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n/a Ensembl ENSG00000125844 n/a UniProt Q9P2E9 n/a RefSeq (mRNA) NM_004587 NM_001042576 NM_001365613 n/a RefSeq (protein) NP_001036041 NP_004578 NP_001352542 n/a Location (UCSC) Chr 20: 17.61 – 17.68 Mb n/a PubMed search n/a Wikidata View/Edit Human Ribosome-binding protein 1, also referred to as p180, is a protein that in humans is encoded by the RRBP1 gene. RRBP1 is a membrane-bound ...