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Angular cheilitis typically starts with a red dry patch on the corners of the mouth. It can be on one or both sides, with a dry, scaly appearance, according to the Cleveland Clinic.
Angular cheilitis is thought to be a multifactorial disorder of infectious origin, [10] with many local and systemic predisposing factors. [11] The sores in angular cheilitis are often infected with fungi (yeasts), bacteria, or a combination thereof; [8] this may represent a secondary, opportunistic infection by these pathogens.
Atrophic glossitis is a non-specific finding, [16] and has a great many causes, usually related to iron-deficiency anemia, pernicious anemia, B vitamin complex deficiencies, [16] unrecognized and untreated celiac disease (which often presents without gastrointestinal symptoms), [17] [18] [19] or other factors such as xerostomia (dry mouth).
Psychogenic polydipsia caused by psychiatric disorders—oftentimes schizophrenia—is frequently accompanied by the sensation of dry mouth. Some conditions with polydipsia as a symptom are non-psychogenic (e.g., early Type 2 diabetes, primary hyperaldosteronism, and zinc deficiency, and some forms of diabetes insipidus).
Salivary gland dysfunction affects the flow, amount, or quality of saliva produced. A reduced salivation is termed hyposalivation.Hyposalivation often results in a dry mouth condition called xerostomia, and this can cause tooth decay due to the loss of the protective properties of saliva.
Xerostomia is the subjective sensation of dry mouth, which is often (but not always) associated with hypofunction of the salivary glands. [3] The term is derived from the Greek words ξηρός (xeros) meaning "dry" and στόμα (stoma) meaning "mouth". [4] [5] A drug or substance that increases the rate of salivary flow is termed a sialogogue.
Enlargement of the perioral and periorbital soft tissues (the tissues of the face around the mouth and the eyes). The facial skin may be dry, exfoliative (flaking) or erythematous. [2] Cervical lymphadenopathy (enlarged lymph nodes in the neck). [2] Facial palsy (weakness and altered sensation of the face). [2]
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