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22095 Ensembl ENSG00000165409 ENSMUSG00000020963 UniProt P16473 P47750 RefSeq (mRNA) NM_000369 NM_001018036 NM_001142626 NM_001113404 NM_011648 RefSeq (protein) NP_000360 NP_001018046 NP_001136098 NP_001106875 NP_035778 Location (UCSC) Chr 14: 80.95 – 81.15 Mb Chr 12: 91.35 – 91.52 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The thyrotropin receptor (or TSH receptor) is a ...
Thyroid-stimulating hormone (also known as thyrotropin, thyrotropic hormone, or abbreviated TSH) is a pituitary hormone that stimulates the thyroid gland to produce thyroxine (T 4), and then triiodothyronine (T 3) which stimulates the metabolism of almost every tissue in the body. [1]
The thyrotropin receptor (TSH receptor) is the antigen for TSH receptor antibodies (TRAbs). It is a seven transmembrane G protein-coupled receptor that is involved in thyroid hormone signalling. TRAbs are grouped depending on their effects on receptor signalling; activating antibodies (associated with hyperthyroidism), blocking antibodies ...
In a healthy individual, the TR-β2 expressed in the pituitary gland plays a major role in regulating thyroid-stimulating hormone (TSH) levels through negative feedback. TSH stimulates the thyroid to secrete thyroid hormone. Once secreted, thyroid hormone acts on these receptors and inhibits transcription of Tshb. This feedback inhibition stops ...
These receptors, together with corepressor molecules, bind DNA regions called thyroid hormone response elements (TREs) near genes. This receptor-corepressor-DNA complex can block gene transcription. Triiodothyronine (T 3), which is the active form of thyroxine (T 4), goes on to bind to receptors.
The TSH, in turn, stimulates the thyroid to produce thyroid hormone until levels in the blood return to normal. Thyroid hormone exerts negative feedback control over the hypothalamus as well as anterior pituitary, thus controlling the release of both TRH from hypothalamus and TSH from anterior pituitary gland.
The receptor affinity for T 3 significantly decreases for thyrotropic tumor cells in culture when compared to healthy thyrotropes, which reduces the regulatory effect. [ 7 ] In addition, during pregnancy , the size of the pituitary gland increases, and consequently, the expression of TSH also increases.
Glycoprotein hormones, alpha polypeptide is a protein that in humans is encoded by the CGA gene. [5]The gonadotropin hormones, human chorionic gonadotropin (hCG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and thyroid-stimulating hormone (TSH) are heterodimers consisting of alpha and beta subunits (also called chains) that are associated non-covalently.