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Unlike in the case of normal cells, state switching in cancer cells is widely believed to arise due to somatic mutations. [4] However, there is growing concern that such a deterministic view of a phenomenon that is reversible is not entirely consistent with multiple lines of evidence which indicate that stochasticity may also play an important ...
[23] [24] Many bodily processes can be affected due to the hereditary nature of this disease; if the disease is present in the DNA of both the sperm and the egg, then it will be present in essentially every cell and organ in the body; these mutations can occur initially in the germline cells, or be present in all parental cells. [23]
For example, in mammals, somatic cells make up the internal organs, skin, bones, blood, and connective tissue. [1] In most animals, separation of germ cells from somatic cells (germline development) occurs during early stages of development. Once this segregation has occurred in the embryo, any mutation outside of the germline cells can not be ...
The condition of a cell or organism lacking all of the copies of a particular chromosome that are normal for its ploidy level; e.g. in a diploid organism, lacking both members of the normal pair. Nullisomy is frequently lethal early in development. nullizygous
Such mutations are responsible for diseases such as Epidermolysis bullosa, sickle-cell disease, and SOD1-mediated ALS. [52] On the other hand, if a missense mutation occurs in an amino acid codon that results in the use of a different, but chemically similar, amino acid, then sometimes little or no change is rendered in the protein.
Polyploidy is the result of whole-genome duplication during the evolution of species. It may occur due to abnormal cell division, either during mitosis, or more commonly from the failure of chromosomes to separate during meiosis or from the fertilization of an egg by more than one sperm. [1]
It can also be achieved experimentally using laboratory procedures. A mutagen is a mutation-causing agent, be it chemical or physical, which results in an increased rate of mutations in an organism's genetic code. In nature mutagenesis can lead to cancer and various heritable diseases, and it is also a driving force of evolution.
This is an accepted version of this page This is the latest accepted revision, reviewed on 29 December 2024. Science of genes, heredity, and variation in living organisms This article is about the general scientific term. For the scientific journal, see Genetics (journal). For a more accessible and less technical introduction to this topic, see Introduction to genetics. For the Meghan Trainor ...