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Excessive QT prolongation can trigger tachycardias such as torsades de pointes (TdP). QT prolongation is an established side effect of antiarrhythmics, but can also be caused by a wide range of non-cardiac medicines, including antibiotics, antidepressants, antihistamines, opioids, and complementary medicines.
It is also used in chemotherapy as a single drug as well as with other antiemetics such as 5-HT 3 receptor antagonists and NK1 receptor antagonist, but the specific mechanism of action is not fully understood. [17] Other Trimethobenzamide is thought to work on the CTZ; Ginger contains 5-HT 3 antagonists gingerols, shogaols, [18] and ...
The Arizona Center for Education and Research on Therapeutics (AZCERT) maintains the CredibleMeds database. Founded in 2000 at the University of Arizona as part of a network of 14 federally-funded CERTs, [9] AZCERT became a separate non-profit corporation in 2012 funded by the US Food and Drug Administration (FDA), research grants, and charitable contributions.
All 5-HT 3 antagonists have been associated with asymptomatic electrocardiogram changes, such as prolongation of the PT and QTc intervals and certain arrhythmias. [28] The clinical significance of these side effects is unknown.
In 2001, the FDA changed the labeling requirements for droperidol injection to include a Black Box Warning, citing concerns of QT prolongation and torsades de pointes.The evidence for this is disputed, with 9 reported cases of torsades in 30 years and all of those having received doses in excess of 5 mg. [9] QT prolongation is a dose-related effect, [10] and it appears that droperidol is not a ...
[19] [39] Almost half of patients with type 1 diabetes have a prolonged QTc interval (> 440 ms). [19] Diabetes with a prolonged QTc interval was associated with a 29% mortality over 10 years in comparison to 19% with a normal QTc interval. [19] Anti-hypertensive drugs increased the QTc interval, but were not an independent predictor of ...
It may produce less QT interval prolongation than zotepine, as in one patient who had previously been on zotepine switching to perospirone corrected their prolonged QT interval. [11] It also tended to produce less severe extrapyramidal side effects than haloperidol in a clinical trial comparing the two (although statistical significance was not ...
Serious side effects include QT prolongation and severe allergic reaction. [8] It appears to be safe during pregnancy but has not been well studied in this group. [8] It is a serotonin 5-HT 3 receptor antagonist. [8] It does not have any effect on dopamine receptors or muscarinic acetylcholine receptor and therefore does not cause akathisia. [11]