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Unusual types of MS have been described; these include Devic's disease, Balo concentric sclerosis, Schilder's diffuse sclerosis, and Marburg multiple sclerosis. There is debate on whether they are MS variants or different diseases. [31] Multiple sclerosis behaves differently in children, taking more time to reach the progressive stage. [5]
The McDonald criteria for the diagnosis of multiple sclerosis were revised first in 2005 to clarify exactly what is meant by an "attack", "dissemination" and a "positive MRI", etc. [1] Later they were revised again in 2017. [6] McDonald criteria are the standard clinical case definition for MS and the 2010 version is regarded as the gold ...
The graver course is one form of malignant multiple sclerosis, with patients reaching a significant level of disability in less than five years from their first symptoms, often in a matter of months. [2] Sometimes Marburg MS is considered a synonym for tumefactive MS, [3] but not for all authors. [citation needed]
It consists of ordinal rating system ranging from 0 (normal neurological status) to 10 (death due to MS) in 0.5 increments interval (when reaching EDSS 1). The lower scale values of the EDSS measure impairments based on the neurological examination, while the upper range of the scale (> EDSS 6) measures handicaps of patients with MS.
A new study found that in about 10% cases of multiple sclerosis, the body begins producing a distinctive set of antibodies against its own proteins years before symptoms emerge. “Multiple ...
Compression of the upper spinal cord, multiple sclerosis, transverse myelitis, Behçet's disease, osteogenesis imperfecta In neurology , Lhermitte phenomenon , also called the barber chair phenomenon , is an uncomfortable "electrical" sensation that runs down the back and into the limbs.
Diagnosis of MS has always been made by clinical examination, supported by MRI or CSF tests. According with both the pure autoimmune hypothesis and the immune-mediated hypothesis, [5] researchers expect to find biomarkers able to yield a better diagnosis, and able to predict the response to the different available treatments. [6]
Mysterious skeletal remains found lodged inside the chimney of a Wisconsin music store have fueled speculation and frustrated investigators for more than 30 years — but DNA analysis recently ...