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The myosin-binding protein C, cardiac-type is a protein that in humans is encoded by the MYBPC3 gene. [5] This isoform is expressed exclusively in heart muscle during human and mouse development, [6] and is distinct from those expressed in slow skeletal muscle and fast skeletal muscle ().
The two main myofilaments in cardiac (and skeletal) muscle are actin and myosin. Ca 2+ binds to a protein called troponin, which is bound to the actin filament. This binding causes a shape change in the troponin which exposes areas on the actin, to which the head of the myosin filament binds. The binding of the myosin head to actin is known as ...
The cardiac myosin binding protein C mutation identified in Maine Coon cats has not been found in any other breed of cat with HCM, but more recently another myosin binding protein C mutation has been identified in Ragdoll cats with HCM. [79] [80] As in humans, feline HCM is not present at birth but develops over time. It has been identified for ...
This gene encodes a member of the myosin-binding protein C family. This family includes the fast-, slow- and cardiac-type isoforms, each of which is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The protein encoded by this locus is referred to as the fast-type isoform.
When calcium becomes bound to specific sites in the N-domain of TnC, a series of protein structural changes occurs, [citation needed] such that tropomyosin is rolled away from myosin-binding sites on actin, allowing myosin to attach to the thin filament and produce force and shorten the sarcomere. [citation needed]
MHC-β is a 223 kDa protein composed of 1935 amino acids. [7] [8] MHC-β is a hexameric, asymmetric motor forming the bulk of the thick filament in cardiac muscle.MHC-β is composed of N-terminal globular heads (20 nm) that project laterally, and alpha helical tails (130 nm) that dimerize and multimerize into a coiled-coil motif to form the light meromyosin (LMM), thick filament rod. [9]
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) also known as the regulatory light chain of myosin (RLC) is a protein that in humans is encoded by the MYL2 gene. [ 5 ] [ 6 ] This cardiac ventricular RLC isoform is distinct from that expressed in skeletal muscle ( MYLPF ), smooth muscle ( MYL12B ) and cardiac atrial ...
4624 17888 Ensembl ENSG00000197616 ENSMUSG00000040752 UniProt P13533 Q02566 RefSeq (mRNA) NM_002471 NM_001164171 NM_010856 RefSeq (protein) NP_002462 NP_001157643 NP_034986 Location (UCSC) Chr 14: 23.38 – 23.41 Mb Chr 14: 55.18 – 55.2 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Myosin heavy chain, α isoform (MHC-α) is a protein that in humans is encoded by the MYH6 gene ...
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