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MELAS (Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like episodes) is one of the family of mitochondrial diseases, which also include MIDD (maternally inherited diabetes and deafness), MERRF syndrome, and Leber's hereditary optic neuropathy. It was first characterized under this name in 1984. [2]
Stroke-like episodes are a prevalent feature in this syndrome, but do not follow typical vascular stroke patterns in terms of affected brain regions. The most commonly involved areas are the occipital, parietal, and temporal lobes. [5]
The five most common are MELAS, MERF, KSS, CPEO, and MNGIE which are listed below: [9] Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like syndrome (MELAS) Varying degrees of cognitive impairment and dementia; Lactic acidosis; Strokes; Transient ischemic attacks; Hearing loss; Weight loss; Myoclonic epilepsy and ragged-red fibers ...
Multiple mtDNA abnormalities exist which cause CPEO. One mutation is located in a conserved region of mitochondrial tRNA at nucleotide 3243 in which there is an A to G nucleotide transition. This mutation is associated with both CPEO and mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). [4]
Paris Hilton has expanded her pet grooming line to now offer food products.. Pamper Like Paris is a new food line, available at Chewy, that the multi-hyphenate star, 43, crafted in collaboration ...
Sonlicromanol was principally developed as drug to release symptoms for patients with mitochondrial diseases like Leigh's disease, MELAS (Mitochondrial, Encephalomyopathy, Lactic acidosis, and Stroke-like episodes) spectrum disorders, and LHON (Leber's Hereditary Optic Neuropathy).
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