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  2. Abiraterone acetate - Wikipedia

    en.wikipedia.org/wiki/Abiraterone_acetate

    Abiraterone acetate is used in combination with prednisone, a corticosteroid, as a treatment for mCRPC (previously called hormone-resistant or hormone-refractory prostate cancer). [2] [6] [5] [4] This is a form of prostate cancer that is not responding to first-line androgen deprivation therapy or treatment with androgen receptor antagonists.

  3. CYP17A1 inhibitor - Wikipedia

    en.wikipedia.org/wiki/CYP17A1_inhibitor

    CYP17A1 inhibitors, such as abiraterone acetate, are primarily used in the treatment of prostate cancer. These drugs reduce androgen levels, which helps to slow the progression of prostate cancer in patients with castration-resistant prostate cancer. [4]

  4. Niraparib/abiraterone acetate - Wikipedia

    en.wikipedia.org/wiki/Niraparib/abiraterone_acetate

    Niraparib/abiraterone acetate, sold under the brand name Akeega, is a fixed-dose combination anti-cancer medication used for the treatment of prostate cancer. [2] It contains niraparib , a poly (ADP-ribose) polymerase (PARP) inhibitor (antineoplastic agent), and abiraterone acetate , a CYP17 inhibitor (hormone antagonist).

  5. Androgen deprivation therapy - Wikipedia

    en.wikipedia.org/wiki/Androgen_deprivation_therapy

    Androgen deprivation therapy (ADT), also called androgen ablation therapy or androgen suppression therapy, is an antihormone therapy whose main use is in treating prostate cancer. Prostate cancer cells usually require androgen hormones, such as testosterone, to grow. ADT reduces the levels of androgen hormones, with drugs or surgery, to prevent ...

  6. 3-Keto-5α-abiraterone - Wikipedia

    en.wikipedia.org/wiki/3-Keto-5α-abiraterone

    3-Keto-5α-abiraterone, also known as 17-(3-pyridyl)-5α-androst-16-en-3-one, is an active metabolite of abiraterone acetate that has been found to possess androgenic activity and to stimulate prostate cancer progression.

  7. Antiandrogen - Wikipedia

    en.wikipedia.org/wiki/Antiandrogen

    1989: Flutamide is first introduced for medical use in the United States, to treat prostate cancer [238] 1989: Flutamide is first studied in the treatment of hirsutism in women [9] 1992: The androgen synthesis inhibitor abiraterone acetate is first described [239] 1995: Bicalutamide is first introduced for medical use, to treat prostate cancer ...