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We assessed the probability that each statin has the most favorable harm profile by calculating its treatment effect compared with control treatment and counting the proportion of iterations for which each statin has the highest treatment effect (ie, least harmful), the second highest, and so on.
While statins are highly effective and safe for most people, they have been linked to muscle pain, digestive problems and mental fuzziness in some people. Rarely, they may cause liver damage. If you think you're experiencing side effects from taking statins, don't just stop taking the pills.
According to dose-level comparisons, individual statins resulted in higher odds of discontinuations with higher doses of atorvastatin and rosuvastatin. Similarly, higher doses of atorvasatin, fluvastatin, lovastatin, and simvastatin were associated with higher odds of transaminase elevations.
Though there is no consensus on a single safest statin, some people may find some statin types more tolerable. Also, adjusting your dosage or managing underlying conditions like vitamin D deficiency may relieve statin-related side effects.
What is the difference between statins, and which is the most effective? Compare the intensity of lovastatin, atorvastatin, and other statins here.
The major adverse reaction limiting statin use is the development of muscle symptoms, a condition known as statin-associated muscle symptoms (SAMS). This problem, including predisposing drug interactions, is discussed in detail separately. (See "Statin muscle-related adverse events".)