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Chaperone-mediated autophagy (CMA) refers to the chaperone-dependent selection of soluble cytosolic proteins that are then targeted to lysosomes and directly translocated across the lysosome membrane for degradation. [1][2] The unique features of this type of autophagy are the selectivity on the proteins that are degraded by this pathway and ...
Autophagy (or autophagocytosis; from the Ancient Greek αὐτόφαγος, autóphagos, meaning "self-devouring" [1] and κύτος, kýtos, meaning "hollow") [2] is the natural, conserved degradation of the cell that removes unnecessary or dysfunctional components through a lysosome-dependent regulated mechanism. [3] It allows the orderly ...
The chaperone-assisted selective autophagy is dependent on the formation of a heteromeric complex. This consists of the heat shock proteins and BAG3. The BAG family has 6 cochaperone members and BAG1 was identified as an interactor of Bcl-2 proteins which is an anti-apoptotic protein. The activation of HSF1 is the primary mechanism by which ...
Yoshinori Ohsumi (大隅 良典, Ōsumi Yoshinori, born February 9, 1945) is a Japanese cell biologist specializing in autophagy, the process that cells use to destroy and recycle cellular components. Ohsumi is a professor at Tokyo Institute of Technology 's Institute of Innovative Research. [1] He received the Kyoto Prize for Basic Sciences in ...
Ketogenic diet. Testing for ketone bodies in urine. The ketogenic diet is a high-fat, adequate- protein, low-carbohydrate dietary therapy that in conventional medicine is used mainly to treat hard-to-control (refractory) epilepsy in children. The diet forces the body to burn fats rather than carbohydrates.
Fasting is abstention from eating, and sometimes drinking. However, from a purely physiological context, "fasting" may refer to the metabolic status of a person who has not eaten overnight (before "breakfast"), or to the metabolic state achieved after complete digestion and absorption of a meal. [1] Metabolic changes in the fasting state begin ...
Alternate fasting schedule Some people follow the plan simply by fasting every other day and eating normally in between. Others favor the modified 5:2 approach where you eat whatever you want for ...
Autophagia. Autophagia is the practice of biting/consuming one's body. It is a sub category of self-injurious behavior (SIB). [1] Commonly, it manifests in humans as nail biting and hair pulling. In rarer circumstances, it manifests as serious self mutilative behavior such as biting off one's fingers. [2] Autophagia affects both humans and non ...