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Methylcobalamin and cyanocobalamin are the two most common sources of vitamin B12. We look at their main differences and their benefits.
Methylcobalamin is the active form of vitamin B12 that is used in adults alone or in combination with other vitamins as a dietary supplement. Vitamin B12 is important for the brain and nerves, and to produce red blood cells.
Overview. Vitamin B-12 (cobalamin) plays an essential role in red blood cell formation, cell metabolism, nerve function and the production of DNA, the molecules inside cells that carry genetic information. Food sources of vitamin B-12 include poultry, meat, fish and dairy products.
Methylcobalamin and 5-deoxyadenosylcobalamin are the metabolically active forms of vitamin B12. However, two others forms, hydroxycobalamin and cyanocobalamin, become biologically active after they are converted to methylcobalamin or 5-deoxyadenosylcobalamin [ 1-3 ].
Methylcobalamin is the methyl form of cobalamin obtained from hydroxycobalamin, either by chemical manipulation in the laboratory or in the body as a natural process. Cyano- and hydroxocobalamin are considered the storage or transport forms of cobalamin, while methylcobalamin and deoxyadenosylcobalamin are the active forms involved in enzymatic ...
Methylcobalamin is the active form of vitamin B12. Cyanocobalamin, which must be processed by the body into the active form, is the most common type used in supplements. People commonly use...
Methylcobalamin is a form of vitamin B12 that plays a crucial role in maintaining proper brain function, nerve health, and the production of red blood cells. It is a naturally occurring compound that can be found in various animal-based foods such as meat, fish, eggs, and dairy products.
Methylcobalamin is a natural form of vitamin B12, and cyanocobalamin is synthetic. The two forms also differ in structure—methylcobalamin contains a methyl group, and cyanocobalamin contains a cyanide compound.
The two most common donors in supplements are cyanide (making the type of B12 known as cyanocobalamin, or cyano B12) and methyl (making what’s known as methylcobalamin, or methyl B12). Two other forms you may find are hydroxocobalamin and adenosylcobalamin.
Vitamin B12 is available in multivitamin/multimineral supplements, in B-complex supplements, and in supplements containing only vitamin B12. It is usually in a form called cyanocobalamin. Other common forms are adenosylcobalamin, methylcobalamin, and hydroxycobalamin.