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The letter reported on an examination of medical files of patients who had been hospitalized and treated with small doses of opioids.The authors concluded that of the 11,882 patients who received at least one narcotic drug, only four of them had developed a "reasonably well documented" addiction among patients who had no history of addiction.
The New England Journal of Medicine (NEJM) is a weekly medical journal published by the Massachusetts Medical Society. Founded in 1812, the journal is among the most prestigious peer-reviewed medical journals. [1] Its 2023 impact factor was 96.2, ranking it 2nd out of 168 journals in the category "Medicine, General & Internal". [2]
Binding of oxygen to a heme prosthetic group. Heme (American English), or haem (Commonwealth English, both pronounced /hi:m/ HEEM), is a ring-shaped iron-containing molecular component of hemoglobin, which is necessary to bind oxygen in the bloodstream.
NEJM Journal Watch is a series of topic-specific newsletters written for physicians and other health professionals. It is published by the Massachusetts Medical Society and is a sibling publication to the New England Journal of Medicine. NEJM Journal Watch distributes its products via print, e-mail, and its website.
In some centers "hematology/oncology" is a single subspecialty of internal medicine while in others they are considered separate divisions (there are also surgical and radiation oncologists). Not all hematological disorders are malignant ("cancerous"); these other blood conditions may also be managed by a hematologist.
Oncology is a branch of medicine that deals with the study, treatment, diagnosis, and prevention of cancer.A medical professional who practices oncology is an oncologist. [1]
Checkpoint inhibitor therapy is a form of cancer immunotherapy.The therapy targets immune checkpoints, key regulators of the immune system that when stimulated can dampen the immune response to an immunologic stimulus.
Hemin is protoporphyrin IX containing a ferric iron (Fe 3+) ion with a coordinating chloride ligand.. Chemically, hemin differs from the related heme-compound hematin chiefly in that the coordinating ion is a chloride ion in hemin, whereas the coordinating ion is a hydroxide ion in hematin. [2]