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Apixaban is recommended by the National Institute for Health and Clinical Excellence for the prevention of stroke and systemic embolism in people with non-valvular atrial fibrillation and at least one of the following risk factors: prior stroke or transient ischemic attack, age 75 years or older, diabetes, or symptomatic heart failure.
Side effects may include bleeding, most commonly from the nose, gastrointestinal tract (GI) or genitourinary system. [2] Compared to the risk of bleeding with warfarin use, direct factor Xa inhibitors have a higher risk of GI bleeding, but lower risk of bleeding in the brain. [2]
The p-methoxy group of apixaban connects to S1 pocket of FXa but does not appear to have any interaction with any residues in this region of FXa. The pyrazole N-2 nitrogen atom of apixaban interacts with Gln-192 and the carbonyl oxygen interacts with Gly-216. The phenyl lactam group of apixaban is positioned between Tyr-99 and Phe-174 and due ...
Even one or two drinks, including beer, may reduce milk intake by 20 to 23%, leading to increased agitation and poor sleep patterns. Regular heavy drinking (more than two drinks daily) can shorten breastfeeding duration and cause issues in infants, such as excessive sedation, fluid retention, and hormonal imbalances.
You can usually hit that level by drinking 12 ounces of beer, 5 ounces of wine, or 1.5 ounces of hard liquor such as whiskey, vodka, rum, or gin. For adult males, an episode of binge drinking is ...
Alcohol inhalation is a method of administering alcohol directly into the respiratory system, with aid of a vaporizing or nebulizing device or bag. It is chiefly applied for recreational use, when it is also referred to as alcohol smoking, but it has medical applications for testing on laboratory rats, and treatment of pulmonary edema and viral pneumonia.
8 cl (4 parts) hot coffee (average 80 mg caffeine), 3 cl (1 + 1 ⁄ 2 parts) fresh cream, 1 tsp brown sugar, 4 cl (2 parts) Irish whiskey (40% (legal definition)) Gunfire: Black tea: 41 mg 35 mg 6% 1 cup of black tea (mean 35 mg caffeine), 1 oz rum (40%) Rev: Cola: 38 mg 8 mg 7% 473 ml cola (37.84 mg caffeine: cola contains 8 mg/100 ml in ...
Khamr (Arabic: خمر) is an Arabic word for wine or intoxicant. [a] It is variously defined as alcoholic beverages, wine or liquor. [1] In fiqh, it refers to certain forbidden substances, and its technical definition depends on the madhhab or legal school.