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In MCTD, major histocompatibility complex (MHC) and non-MHC genes have been linked to disease vulnerability. [10] HLA-DR4 in the MHC is linked to both anti-RNP antibody responses and MCTD. [ 52 ] [ 53 ] The HLA class II phenotype/genotype most closely connected with scleroderma , HLA-DR5 , and its subgroups, has been demonstrated to have a ...
Examples of overlap syndromes in rheumatology include mixed connective tissue disease and scleromyositis. Diagnosis depends on which diseases the patient shows symptoms and has positive antibodies for in their lab serology. In overlap syndrome, features of the following diseases are found (most common listed): [1] Systemic lupus erythematosus (SLE)
The term is sometimes used interchangeably with mixed connective tissue disease (MCTD), as it is an overlap syndrome. However, some researchers believe that MCTD is a clinically distinct entity and is strongly associated with the presence of titer high in antibodies Ribonucleoproteins (RNP). [4]
Connective tissue diseases can be classified into two groups: (1) a group of relatively rare genetic disorders affecting the primary structure of connective tissue; and (2) a number of acquired conditions where the connective tissues are the site of multiple, more or less distinct immune and inflammatory reactions.
People with scleromyositis have symptoms of both systemic scleroderma and either polymyositis or dermatomyositis, and is therefore considered an overlap syndrome. Although it is a rare disease, it is one of the more common overlap syndromes seen in scleroderma patients, together with MCTD and Antisynthetase syndrome.
Lupus erythematosus–lichen planus overlap syndrome (lichen planus–lupus erythematosus overlap syndrome) Methotrexate-induced papular eruption; Mixed connective tissue disease (Sharp's syndrome, undifferentiated connective tissue disease) Morphea profunda; Morphea–lichen sclerosus et atrophicus overlap
This category reflects the organization of International Statistical Classification of Diseases and Related Health Problems, 10th Revision. Generally, diseases outlined within the ICD-10 codes M30-M36 within Chapter XIII: Diseases of the musculoskeletal system and connective tissue should be included in this category.
This is a shortened version of the thirteenth chapter of the ICD-9: Diseases of the Musculoskeletal System and Connective Tissue.It covers ICD codes 710 to 739.The full chapter can be found on pages 395 to 415 of Volume 1, which contains all (sub)categories of the ICD-9.