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Venlafaxine was originally marketed as Effexor in most of the world; generic venlafaxine has been available since around 2008 and extended-release venlafaxine has been available since around 2010. [94] Venlafaxine is sold under many brand names worldwide. [1] In some countries, Effexor is marketed by Viatris after Upjohn was spun off from Pfizer.
This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification.
In the short run, this leads to an increase in signaling across synapses in which serotonin serves as the primary neurotransmitter. On chronic dosing, the increased occupancy of post-synaptic serotonin receptors signals the pre-synaptic neuron to synthesize and release less serotonin.
Effexor and Effexor XR (venlafaxine) – an antidepressant of the SNRI class Elavil ( amitriptyline ) – a tricyclic antidepressant used as a first-line treatment for neuropathic pain Eurodin , Prosom ( estazolam ) – a benzodiazepine derivative with anxiolytic , anticonvulsant , hypnotic , sedative and skeletal muscle relaxant properties ...
When SSRIs have (1) inhibited the re-uptake pump, (2) increased somatodendritic 5-HT, (3) desensitized somatodendritic 5-HT 1A autoreceptors, (4) turned on the impulse flow and (5) increased the release of 5-HT from axon terminal, the last step might be desensitization of postsynaptic 5-HT receptors.
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Venlafaxine was the first compound described in a new class of antidepressant substances called phenylethylamines. These substances are unrelated to TCA and other SSRIs. Venlafaxine blocks the neuronal reuptake of serotonin, noradrenaline and, to a lesser extent, dopamine in the central nervous system.
This is a list of investigational antidepressants, or drugs that are currently under development for clinical use in the treatment of depression but are not yet approved. . Specific indications include major depressive disorder, treatment-resistant depression, dysthymia, bipolar depression, and postpartum depression, among oth