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Hereditary nonpolyposis colorectal cancer (HNPCC) is a hereditary predisposition to colon cancer.. HNPCC includes (and was once synonymous with) [1] Lynch syndrome, an autosomal dominant genetic condition that is associated with a high risk of colon cancer, endometrial cancer (second most common), ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin. [2]
These were called the Amsterdam II clinical criteria for families with Lynch syndrome. [4] [6] Each of the following criteria must be fulfilled: 3 or more relatives with an associated cancer (colorectal cancer, or cancer of the endometrium, small intestine, ureter or renal pelvis); 2 or more successive generations affected;
Women with Lynch syndrome have a 40–60% risk of developing endometrial cancer, higher than their risk of developing colorectal (bowel) or ovarian cancer. [17] Ovarian and endometrial cancer develop simultaneously in 20% of people. Endometrial cancer nearly always develops before colon cancer, on average, 11 years before. [18]
Endometrial cancer, on the other hand, seems to be a more important clinical manifestation for female mutation carriers. The onset of endometrial cancer and also colon cancer in families with hMSH6 mutations is about 50 years. This is delayed compared to the age 44 onset of hMSH2-related tumors. [11]
Dr. Henry Lynch's name is attached to a condition, Lynch Syndrome (formerly Hereditary Nonpolyposis Colorectal Cancer, HNPCC), characterized by a greatly increased risk of colorectal and endometrial cancer, plus a moderately increased risk of ~7 other cancers. In 1992 collaborations between Finnish, US, New Zealand and Canadian researchers had ...
Endometrial cancer is the most common form of cancer of the female reproductive organs in the U.S., with 67,880 new cases diagnosed each year. Over the past decades, rates have increased and ...
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