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Sonidegib , sold under the brand name Odomzo, is a medication used to treat cancer. [ 1 ] Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism).
Sonidegib was created by Novartis. It is a SMO antagonist that can induce arrest of cell division and promote apoptosis in cancer cells. [14] Sonidegib has been effective in limiting the invasive potential of multiple cancer types including glioblastoma, [38] prostate cancer, [39] and renal cell carcinoma. [40]
Several hedgehog signaling pathway inhibitors are available for cancer treatment, such as vismodegib and sonidegib. These drugs are regarded as promising cancer therapies, especially for patients with refractory/advanced cancers. SMO inhibitors represent a potential treatment for some types of cancers.
Vismodegib, sold under the brand name Erivedge, is a medication used for the treatment of basal-cell carcinoma (BCC). [3] The approval of vismodegib on January 30, 2012, represents the first Hedgehog signaling pathway targeting agent to gain U.S. Food and Drug Administration (FDA) approval. [4]
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Publications and patents from Beachy’s laboratory have now led to the FDA approval of three Hedgehog pathway inhibitors (vismodegib, sonidegib, and glasdegib, all cyclopamine mimics) that have been approved by the FDA as therapeutics for advanced basal cell carcinoma and acute myelogenous leukemia, with therapeutic use for additional Hedgehog ...
Pulmonary Arterial Hypertension. Pulmonary arterial hypertension (PAH) is a serious condition that happens when the tiny vessels in your lungs narrow, resulting in high blood pressure.
Move over, Wordle, Connections and Mini Crossword—there's a new NYT word game in town! The New York Times' recent game, "Strands," is becoming more and more popular as another daily activity ...
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