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  2. Chronic myelogenous leukemia - Wikipedia

    en.wikipedia.org/wiki/Chronic_myelogenous_leukemia

    Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a cancer of the white blood cells.It is a form of leukemia characterized by the increased and unregulated growth of myeloid cells in the bone marrow and the accumulation of these cells in the blood.

  3. Chronic myelomonocytic leukemia - Wikipedia

    en.wikipedia.org/wiki/Chronic_myelomonocytic...

    Chronic myelomonocytic leukemia (CMML) is a type of leukemia, which are cancers of the blood-forming cells of the bone marrow.In adults, blood cells are formed in the bone marrow, by a process that is known as haematopoiesis.

  4. Bcr-Abl tyrosine-kinase inhibitor - Wikipedia

    en.wikipedia.org/wiki/Bcr-Abl_tyrosine-kinase...

    CML has a well defined molecular target and relatively selective therapies aimed at that target, which is not the case for the majority of cancers and chemotherapies today. [4] Bcr-Abl was regarded as highly attractive target for drug intervention since the Bcr-Abl fusion gene encodes a constitutively activated kinase.

  5. Leukemia - Wikipedia

    en.wikipedia.org/wiki/Leukemia

    Chronic myelogenous leukemia can be treated with relative safety at any time during pregnancy with Interferon-alpha hormones. [104] Treatment for chronic lymphocytic leukemias, which are rare in pregnant women, can often be postponed until after the end of the pregnancy.

  6. Myelodysplastic syndrome - Wikipedia

    en.wikipedia.org/wiki/Myelodysplastic_syndrome

    These conditions were lumped together with other diseases under the term "refractory anemia". The first description of "preleukemia" as a specific entity was published in 1953 by Block et al. [ 60 ] The early identification, characterization and classification of this disorder were problematical, and the syndrome went by many names until the ...

  7. Atypical chronic myeloid leukemia - Wikipedia

    en.wikipedia.org/wiki/Atypical_Chronic_Myeloid...

    In aCML many clinical features (splenomegaly, myeloid predominance in the bone marrow with some dysplastic features but without a differentiation block) and laboratory abnormalities (myeloid proliferation, low leukocyte alkaline phosphatase values) suggest the diagnosis of chronic myelogenous leukemia (CML).

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