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Detergent and surfactant microbicides such as nonoxynol-9, sodium dodecyl sulfate and Savvy (1.0% C31G), act by disrupting the viral envelope, capsid or lipid membrane of microorganisms. Since detergent microbicides also kill host cells and impair the barrier function of healthy mucosal surfaces, they are less desirable than other agents ...
Nonoxynol-9 is a common ingredient of most vaginal and anal lubricants due to its spermicidal properties. A 2004 study found that over a six-month period, the typical-use failure rates for five nonoxynol-9 vaginal contraceptives (film, suppository, and gels at three different concentrations) ranged from 10% to 20%.
The most commonly discussed compound nonoxynol-9 is a spermicide, formulated primarily as a component of vaginal foams and creams. Nonoxynol was found to metabolize into free nonylphenol when administered to lab animals. [1] Arkopal-N60, with on average 6 ethylene glycol units is a related used surfactant.
Most spermicides, which come in films, foams and more, rely on a chemical, nonoxynol-9, which kills sperm by destroying their cellular membranes. Culwell expained that nonoxynol-9 can be dangerous ...
The most common active ingredient of spermicides is nonoxynol-9. Spermicides containing nonoxynol-9 are available in many forms, such as jelly (gel), films, and foams. Used alone, spermicides have a perfect use failure rate of 6% per year when used correctly and consistently, and 16% failure rate per year in typical use. [1]
The Today sponge is a brand of plastic contraceptive sponge saturated with a spermicide nonoxynol-9 to prevent conception. [1] While initially popular in the 1980s in the United States, it is no longer commercially available as of 2019.